Natural Factors MSM Joint Formula - Bonus Size - A safe, effective, natural way to ease joint pain and promote healing of cartilage and connective tissue. Natural Factors MSM Joint Formula is a combination of Glucosamine Sulfate, a potent, natural anti-inflammatory agent known for its ability to help protect and rebuild cartilage tissue, Chondroitin Sulfate, known and used extensively for its ability to inhibit enzyme break-down of cartilage tissue and joints, and MSM, another well-recognized, natural anti-inflammatory healing agent. Combined, these natural healers work synergistically to provide pain relief from damaged connective tissue, and has powerful healing and maintenance properties that will help restore joint and cartilage health.