Natural Factors B12 Methylcobalamin - 1000 mcg - Bonus Size - A biologically active form of B12 in quick-dissolve sublingual form for easy absorption and longer circulation. Clinical human studies show that supplementation of sublingual B12 can reduce homocysteine levels, reducing the risk factor for heart disease and stroke, as well as arthritis, diabetes and renal failure. Taking Vitamin B12 has many other benefits, including restoration of normal sleep patterns and improved moods. B12 deficiency is fairly common, especially in the elderly and vegetarians. Methylcobalamin is a coenzyme form of Vitamin B12. A coenzyme is a naturally occurring compound, such as a vitamin or mineral, that partners with specific enzymes to help maintain the body’s ability to metabolize nutrients. Preformed coenzyme forms of B vitamins, including methylcobalamin, offer immediate, direct nutritional support, even for those with genetic differences that impair metabolism of standard B vitamins.